Clinical Research

syringe

The University of Nottingham Health Service is an NIHR CRN East Midlands Research Leadership site.

We have over 10 years experience in delivering NHS research, contributing to its future viability and benefiting our patients.

We have a broad portfolio but at the moment we are focused mainly on vaccine and immunity research and studies looking at ways to improve the mental health of younger people.

NOW RECRUITING:

Cloudfree trial 

We are researching a nicotine mouth spray that is aimed at relieving vape cravings. This clinical study is looking to help people quit vaping. The Cloudfree Study is looking at whether an investigational mouth spray, Nicotine Freshmint Mouth spray, may help e-cigarette (‘vape’) users to quit vaping. The study will also look at how safe  the investigational mouth spray is. You or someone you know may be able to take part  if you/they: 

  • are a healthy adult 
  • have been  vaping for at least 3 months 
  • are highly motivated to quit vaping Participants will be assigned to use either the investigational mouth spray or a placebo mouth spray.      

to find out more please contact us on nnicb-nn.research@nhs.net   

Eclipse Migraine trial 

The Eclipse trial is investigating how effective Atogepant (study drug) is in the acute treatment of Migraine attacks. The trial is being run across 8 Centres in the UK including Cripps health centre. To find out more about the study follow this link The ECLIPSE Study (eclipsemigrainestudy.com)

RELIEF asthma trial 

The RELIEF trial is looking at whether a combined inhaler is better for treating mild asthma symptoms. Many UK adults  have “mild” asthma, requiring a reliever (blue) inhaler for symptoms with or without, low-dose-inhaled steroid treatment. Blue inhalers provide symptom relief but cannot help inflammation. Increasing use of blue inhalers and decreasing use of preventer (usually brown) inhalers is associated with poorer asthma outcomes. The Global Initiative for Asthma (world-wide asthma recommendations) suggest replacing the first-choice standard blue inhaler for all asthma patients with a combination inhaler containing both reliever and a preventer medicine. Participants will be selected at random to be in either one of two groups for the trial. Both groups will continue to use their preventer inhaler but one group will receive usual care with a blue reliever inhaler (e.g. Ventolin) and the other will receive a combined reliever + preventer inhaler instead (e.g. Symbicort or Fostair). if you are interested in taking part, please  contact us on  nnicb-nn.research@nhs.net   

Studies in set up/Coming soon:

The PCV15/PCV20 Study

The study will evaluate protection provided by two new vaccines; PCV15 and PCV20 compared to PCV13 given in the current immunisation schedule. Pneumonia, meningitis, and sepsis are serious (sometimes life-threatening) illnesses. They are particularly dangerous in young children, with babies under the age of two having highest risk of developing severe complications. The routine vaccine used currently in babies is PCV13 (Pneumococcal Conjugate Vaccine) that protects against 13 different types of pneumococcal bacteria and has proven effectiveness.  However, there are over 90 different types of pneumococcal bacteria and we have seen an increase in disease caused by types not currently covered by the PCV13 vaccine. We provide an information sheet with more study details when available.

 

Want to have a say in research? Become a Research Champion!

We are recruiting ~10 Research Champion volunteers to get involved with Research at Cripps Health Centre. This will involved quarterly meetings where we discuss new and upcoming research studies. We want your opinions and thoughts on how to promote research to the general public. 

To sign up please email us on nnccg.research@nhs.net or call us on 0115 822 7979 and ask for the Research Team. 

New to Research? Find out more about what Clinical Research is

Starting Out Guide - Why and how to get involved in research | NIHR

What is Health Research? Online Course - FutureLearn

Be Part of Research Podcasts - Be Part of Research (nihr.ac.uk)

Call 111 when you need medical help fast but it’s not a 999 emergencyNHS ChoicesThis site is brought to you by My Surgery Website